This study was accepted by IAMCR 2022 Suzhou Pre-conference. This study used topic modeling to conduct a case study of WeChat official account “Shandong CDC”, introducing the agenda-setting theory. The titles of all articles published by Shandong CDC’s WeChat official account during COVID-19 pandemic was crawled. BitermTopic Model was used to analyze the data. Logistic regression was applied to investigate the relationship between the agenda and public attention.